Drivers are being urged to check the latest weather conditions before setting off as Storm Imogen moves in.
High winds and heavy rain are already causing problems on the roads, with further gusts and downpours to come.
Forecasters predict Southern England and south Wales will bear the brunt of gales, while almost 60 flood warnings and more than 200 flood alerts are in place across England and Wales.
They say high winds will sweep across the Bristol Channel area to Cardiff and Bristol, with gusts of up to 80mph.
Highways England is urging all drivers to be cautious, particularly those behind the wheel of high-sided vehicles.
Winds of 96mph have been recorded at The Needles off the Isle of Wight, with gusts of 73mph in Avonmouth near Bristol.
The Met Office has issued an amber "be prepared" wind warning for Wales, south-west England, London and south-east England. It also warns coastal areas could see giant waves and localised flooding.
Gary Webb, of Highways England, says drivers should plan their journey in advance and check the latest weather conditions, as persistent high winds could lead to bridge closures.
He recommends giving plenty of space to high-sided vehicles, caravans and motorbikes, just in case of a sudden gust of wind.
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