People who work long night shifts face a three times higher risk of accidents, according to a report.
Working through the night can lead to a host of health problems, some of which can impair people's driving ability and affect road safety, the study indicates.
The Young Foundation said staff working long hours late at night often get little exercise and tend to have a poor diet which can bring on fatigue.
Many of these employees also have a "propensity to smoke and drink more", said the report.
It warned that late-night staff could be at risk of cancer and pregnancy problems. The impact of late shifts on social and family life could also have an adverse effect on mental health, the report said.
Campaigners are now urging the Government to ensure that night shifts do not extend beyond eight hours.
The report estimates that around 1.3 million people currently work at night and the number is likely to grow further amid a surge in the 24-hour service economy.
Changing lifestyles mean shops, services and leisure activities remain open later and later into the evening, if not throughout the night, the study found.
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