Thursday is expected to be the busiest day for travel, as around 10 million drivers prepare to take to the road over the holiday period.
The Highways Agency said that 51 sets of roadworks on English motorways and major roads have been suspended until the end of Easter Monday but 32 remain in place.
While last Easter saw travellers contend with bitter weather, this year temperatures could hit 19C (66F) in parts of southern England, encouraging 33% more people to take short trips by road this holiday compared with last Easter, according to the RAC.
The organisation added that all major routes were likely to be busy, forecasting congested roads on Thursday and Friday, with the worst traffic flow being on the M25, the M1 and the M6.
The Highways Agency said it had completed 37 sets of roadworks in time for Easter.
Disrupted rail travel includes the closure of the West Coast Main Line between Milton Keynes in Buckinghamshire and Rugby in the West Midlands from Easter Saturday until 12 noon on Easter Monday.
Temperatures of 19C may be reached on Good Friday and on Easter Saturday with sunshine and showers predicted, before cooler weather on Easter Sunday and Easter Monday, potentially hitting lows of 8C to 9C (46-48F) along eastern coasts.
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