Severe-weather warnings are in force across much of the country, with slippery roads, blizzards and patches of freezing fog forecast for some areas.
Drifting and heavy snow has been predicted after an inch fell on hills in the North West of England, resulting in school closures across Cumbria, Lancashire and Greater Manchester. More is expected overnight in the North of England and Scotland.
Laura Gilchrist, a forecaster at MeteoGroup, the weather division of the Press Association, said: "On Tuesday night, a warm front of air from the west hit a colder front, creating snow.
"By the early hours of Wednesday morning, most parts of the country will be seeing either rain or snow. The worst-hit areas will be the east of the UK, with heavy snow expected in Scotland and the North of England.
"There could be four to eight inches of snow on ground above 150 metres in Scotland and around two inches on high areas in the North of England. It will be accompanied by strong winds, which could create blizzard conditions and drifting."
On Monday, drivers faced difficult conditions after snow fell overnight and rain turned to ice as temperatures dropped to as low as minus 4C in places.
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