The event’s “exit phase” is being made even more challenging by the muddy conditions caused by what organisers say was an “unprecedented amount of rain”.
Tractors and tow crews have been stationed throughout the festival car park to provide assistance, while drivers themselves have been asked to attach towing eyes just in case they are needed.
Organisers have assured local residents that they are doing all they can to make the exodus run as smoothly as possible, but have set up a hotline aimed at offering advice as required.
Traffic warnings were in place for the A37, while organisers said the A631, A39 and B3136 would face closures and disruption.
A major clean-up operation is under way on the 1,000-acre Worthy Farm festival site as it is turned back into farm land. Some 1,800 litter pickers scouring the grounds for rubbish while revellers pack up their tents and head for the exits.
The 135,000 festival-goers are expected to leave behind 500,000 sacks of rubbish, 57 tonnes of reusable items and 1,022 tonnes of recycling, according to the Glastonbury Free Press.
On Sunday evening, headliners Coldplay closed the festival on the Pyramid Stage, bringing on special guests including festival founder Michael Eavis - who performed Frank Sinatra's My Way - and Bee Gees star Barry Gibb.
Towards the end of last week, rain and mud caused chaos on the roads for drivers heading to the festival, with some enduring delays of up to 12 hours.
Major travel disruptions were reported on routes to the Somerset site, prompting police to urge drivers to consider taking their car, caravan or campervan to the festival at a later date.
Drivers leaving Glastonbury today will have to plan their journeys in advance to avoid suffering similar problems on the roads.
They have been asked by organisers to ensure they take everything home with them and to follow the instructions of travel officers to ensure the safest exit.
In a statement they said: “Following the unprecedented amount of rain during the festival build-up, and during the event itself, the car park teams and off-site teams will be working extremely hard to assist both festival goers and local residents in these challenging circumstances.”