The appropriately named Women Talking About Cars programme will be aired on BBC Radio 4 and will be fronted by Victoria Coren Mitchell.
It will take the format of a studio chat show and over the course of the four-part series a different guest will be invited on to discuss their experiences of all things automobile.
Among the names already confirmed for the line-up are comedians Dawn French and Sarah Millican.
They will be joined on the billing by actor Olivia Colman and author Germaine Greer.
Coren Mitchell, who is best known for hosting the BBC quiz show Only Connect, said: “I'm really looking forward to sitting down with some of the greatest women in modern British culture and talking about the pros and cons of the five-speed manual gearbox.”
One of the aims of the show will be to “explore of what cars symbolise to women today, including freedom, power, refuge, novelty and familiarity,” the BBC said.
This will involve using cars “as a vehicle to share memories and take a comic look at life, love, sex, work, childhood, adulthood and adventure”, the broadcaster added.
Members of the public will also be invited to take part in the show, which will begin on November 30 with recording taking place in front of a live audience at the BBC’s Radio Theatre in London.
Ordinary motorists will be encouraged to share their memories on everything from driving to a first job to doing the school run and heading out on picnic trips in a campervan.
Dawn French, who will feature in the first episode of the series, said she is excited about taking part.
“It will be great to get together with Victoria for a good old girly natter about the torque stats on the BMW Luxus 850,” French said.
The announcement of the show comes after the former hosts of the BBC’s flagship motoring programme are set to embark on their next project.
Jeremy Clarkson, James May and Richard Hammond have signed up to make 12 shows of The Grand Tour with Amazon every year for the next three years.
Episodes will be screened on demand through Amazon Prime, with the first installment to be released on November 18.